Structure of the human sodium leak channel NALCN in complex with FAM155A

Structure of the human sodium leak channel NALCN in complex with FAM155A

NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity,...

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Main Authors: Jiongfang Xie, Meng Ke, Lizhen Xu, Shiyi Lin, Jin Huang, Jiabei Zhang, Fan Yang, Jianping Wu, Zhen Yan
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19667-z
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spelling doaj-0ba8b9ca7116497c9d93aa32440a97ed2021-05-11T08:13:58ZengNature Publishing GroupNature Communications2041-17232020-11-0111111310.1038/s41467-020-19667-zStructure of the human sodium leak channel NALCN in complex with FAM155AJiongfang Xie0Meng Ke1Lizhen Xu2Shiyi Lin3Jin Huang4Jiabei Zhang5Fan Yang6Jianping Wu7Zhen Yan8Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityDepartment of Biophysics and Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of MedicineKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityDepartment of Biophysics and Kidney Disease Center, First Affiliated Hospital, Zhejiang University School of MedicineKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake UniversityNALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity, voltage sensing and specific interactions with auxiliary subunits.https://doi.org/10.1038/s41467-020-19667-z
collection DOAJ
language English
format Article
sources DOAJ
author Jiongfang Xie
Meng Ke
Lizhen Xu
Shiyi Lin
Jin Huang
Jiabei Zhang
Fan Yang
Jianping Wu
Zhen Yan
spellingShingle Jiongfang Xie
Meng Ke
Lizhen Xu
Shiyi Lin
Jin Huang
Jiabei Zhang
Fan Yang
Jianping Wu
Zhen Yan
Structure of the human sodium leak channel NALCN in complex with FAM155A
Nature Communications
author_facet Jiongfang Xie
Meng Ke
Lizhen Xu
Shiyi Lin
Jin Huang
Jiabei Zhang
Fan Yang
Jianping Wu
Zhen Yan
author_sort Jiongfang Xie
title Structure of the human sodium leak channel NALCN in complex with FAM155A
title_short Structure of the human sodium leak channel NALCN in complex with FAM155A
title_full Structure of the human sodium leak channel NALCN in complex with FAM155A
title_fullStr Structure of the human sodium leak channel NALCN in complex with FAM155A
title_full_unstemmed Structure of the human sodium leak channel NALCN in complex with FAM155A
title_sort structure of the human sodium leak channel nalcn in complex with fam155a
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description NALCN, a sodium leak channel, plays a key role in regulating the resting membrane potential and controlling neuronal excitability. Here the authors report a cryo-EM structure of human NALCN in complex with FAM155A, that with complementary functional analyses provide insights on its ion selectivity, voltage sensing and specific interactions with auxiliary subunits.
url https://doi.org/10.1038/s41467-020-19667-z
work_keys_str_mv AT jiongfangxie structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT mengke structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT lizhenxu structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT shiyilin structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT jinhuang structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT jiabeizhang structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT fanyang structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT jianpingwu structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
AT zhenyan structureofthehumansodiumleakchannelnalcnincomplexwithfam155a
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