A metabolome-wide characterization of the diabetic phenotype in ZDF rats and its reversal by pioglitazone.

Type 2 diabetes (T2D) is a complex metabolic disease associated with alterations in glucose, lipid and protein metabolism. In order to characterize the biochemical phenotype of the Zucker diabetic fatty (ZDF) rat, the most common animal model for the study of T2D, and the impact of the insulin sensi...

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Bibliographic Details
Main Authors: Thomas J Jönsson, Hans-Ludwig Schäfer, Andreas W Herling, Mark Brönstrup
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6258476?pdf=render