SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital.
<h4>Background</h4>Research has revealed that asymptomatic and pre-symptomatic infections are important contributors to the transmission of SARS-CoV-2 in populations. In Egypt, the true prevalence of infections is veiled due to the low number of screening tests. The aim of this study was...
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doaj-0c2b9435a0c74056b87a98020b29afc42021-08-03T04:33:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01167e025458110.1371/journal.pone.0254581SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital.Samia A GirgisHala M HafezHoda Ezz ElarabBasma SherifMoshira H SabryIman AfifiFatma Elzahraa HassanAmira RedaShaimaa ElsayedAsmaa MahmoudPetra HabebIhab S HabilRasha S HusseinIsis M MossadOssama MansourAshraf OmarAyman M SalehMahmoud El-Meteini<h4>Background</h4>Research has revealed that asymptomatic and pre-symptomatic infections are important contributors to the transmission of SARS-CoV-2 in populations. In Egypt, the true prevalence of infections is veiled due to the low number of screening tests. The aim of this study was to determine the SARS-CoV-2 PCR positivity rate as well the seroprevalence of the SARS-CoV-2 antibodies before the ultimate development of a second wave of the epidemic in Cairo, Egypt.<h4>Methods</h4>Our study was carried out between May 5 and the end of October 2020. It included all patients requiring admission to Ain Shams University hospitals. An interview questionnaire was used to collect demographic and clinical data. Laboratory tests for all participants included RT-PCR and total antibody assay for SARS-CoV-2.<h4>Results</h4>A total of 4,313 subjects were enrolled in our study, with females representing 56% of the sample. Adults and middle-aged individuals represented around 60% of the study sample. The positivity rate of SARS-CoV-2 PCR was 3.84% (95% CI 3.29-4.48), and the SARS-CoV-2 antibody seroprevalence was 29.82% (95% CI: 28.16-31.51). Males showed a higher risk for getting the COVID-19 infection, while middle-age group had significantly higher antibody seroprevalence rates.<h4>Conclusion</h4>SARS-CoV-2 infection imposes a high burden on the community as detected by high seroprevalence rates.https://doi.org/10.1371/journal.pone.0254581 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Samia A Girgis Hala M Hafez Hoda Ezz Elarab Basma Sherif Moshira H Sabry Iman Afifi Fatma Elzahraa Hassan Amira Reda Shaimaa Elsayed Asmaa Mahmoud Petra Habeb Ihab S Habil Rasha S Hussein Isis M Mossad Ossama Mansour Ashraf Omar Ayman M Saleh Mahmoud El-Meteini |
spellingShingle |
Samia A Girgis Hala M Hafez Hoda Ezz Elarab Basma Sherif Moshira H Sabry Iman Afifi Fatma Elzahraa Hassan Amira Reda Shaimaa Elsayed Asmaa Mahmoud Petra Habeb Ihab S Habil Rasha S Hussein Isis M Mossad Ossama Mansour Ashraf Omar Ayman M Saleh Mahmoud El-Meteini SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital. PLoS ONE |
author_facet |
Samia A Girgis Hala M Hafez Hoda Ezz Elarab Basma Sherif Moshira H Sabry Iman Afifi Fatma Elzahraa Hassan Amira Reda Shaimaa Elsayed Asmaa Mahmoud Petra Habeb Ihab S Habil Rasha S Hussein Isis M Mossad Ossama Mansour Ashraf Omar Ayman M Saleh Mahmoud El-Meteini |
author_sort |
Samia A Girgis |
title |
SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital. |
title_short |
SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital. |
title_full |
SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital. |
title_fullStr |
SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital. |
title_full_unstemmed |
SARS-CoV-2 PCR positivity rate and seroprevalence of related antibodies among a sample of patients in Cairo: Pre-wave 2 results of a screening program in a university hospital. |
title_sort |
sars-cov-2 pcr positivity rate and seroprevalence of related antibodies among a sample of patients in cairo: pre-wave 2 results of a screening program in a university hospital. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2021-01-01 |
description |
<h4>Background</h4>Research has revealed that asymptomatic and pre-symptomatic infections are important contributors to the transmission of SARS-CoV-2 in populations. In Egypt, the true prevalence of infections is veiled due to the low number of screening tests. The aim of this study was to determine the SARS-CoV-2 PCR positivity rate as well the seroprevalence of the SARS-CoV-2 antibodies before the ultimate development of a second wave of the epidemic in Cairo, Egypt.<h4>Methods</h4>Our study was carried out between May 5 and the end of October 2020. It included all patients requiring admission to Ain Shams University hospitals. An interview questionnaire was used to collect demographic and clinical data. Laboratory tests for all participants included RT-PCR and total antibody assay for SARS-CoV-2.<h4>Results</h4>A total of 4,313 subjects were enrolled in our study, with females representing 56% of the sample. Adults and middle-aged individuals represented around 60% of the study sample. The positivity rate of SARS-CoV-2 PCR was 3.84% (95% CI 3.29-4.48), and the SARS-CoV-2 antibody seroprevalence was 29.82% (95% CI: 28.16-31.51). Males showed a higher risk for getting the COVID-19 infection, while middle-age group had significantly higher antibody seroprevalence rates.<h4>Conclusion</h4>SARS-CoV-2 infection imposes a high burden on the community as detected by high seroprevalence rates. |
url |
https://doi.org/10.1371/journal.pone.0254581 |
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