Role of Squash Cytology in Intraoperative Diagnosis of Meningioma
Introduction: Primary Central Nervous System (CNS) tumours constitute less than 2% of overall cancers in adults and are the second most frequently encountered tumours in children. Meningiomas form 24-30% of primary intracranial tumours. Most intrinsic brain tumours are soft and gelatinous in co...
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doaj-0c51d935032348c2ab7230c73f4e7d372021-10-08T12:43:35ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2021-08-01158EC16EC2010.7860/JCDR/2021/47878.15260Role of Squash Cytology in Intraoperative Diagnosis of MeningiomaGOWRI PRAKASAM0K KARKUZHALI1VEERARAGHAVAN GURUSAMY2Assistant Professor, Department of Pathology, Government Kilpauk Medical College, Chennai, Tamil Nadu, India.. Assistant Professor, Department of Pathology, Thanjavur Medical College, Thanjavur, Tamil Nadu, India.Assistant Professor, Department of Pathology, Government Kilpauk Medical College, Chennai, Tamil Nadu, India.Introduction: Primary Central Nervous System (CNS) tumours constitute less than 2% of overall cancers in adults and are the second most frequently encountered tumours in children. Meningiomas form 24-30% of primary intracranial tumours. Most intrinsic brain tumours are soft and gelatinous in consistency, smear preparation can readily made which gives excellent cytological details when compared to frozen section as the latter produces ice crystal artifacts. Aim: To assess the diagnostic utility of squash cytological evaluation of meningiomas and its comparison with final histopathological diagnosis. Materials and Methods: The cross-sectional study was done at Thanjavur Medical College, Thanjavur, Tamil Nadu, India for period of three years from January 2015 to December 2017. Total of 54 clinically diagnosed and radiologically suspected case of meningiomas were selected. Smears were prepared from the biopsy samples sent in normal saline and stained by Haematoxylin and Eosin (H&E) method. The cytological features were noted and matched with biopsy findings. Descriptive statistics were used to analyse the results. Results: Total of 54 squash smears with male to female ratio was 1:1.5. Maximum number of cases were seen between 41- 50 years followed by 51-60 years. Complete concordance was obtained in 51 cases (94.44%) and partial concordance was noted in a case due to underestimation of malignancy grade in squash cytology. Out of 54 cases, two cases were found to be discordant with final histopathological diagnosis. Conclusion: Intraoperative squash cytology is easy, rapid, reliable and cost-effective technique for neurosurgical consultation with fairly high accuracy in diagnosing meningiomas. https://jcdr.net/articles/PDF/15260/47878_CE[Ra1]_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdfcentral nervous system tumourscytological-histological comparisoncytomorphological featuressquash smear cytology |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
GOWRI PRAKASAM K KARKUZHALI VEERARAGHAVAN GURUSAMY |
spellingShingle |
GOWRI PRAKASAM K KARKUZHALI VEERARAGHAVAN GURUSAMY Role of Squash Cytology in Intraoperative Diagnosis of Meningioma Journal of Clinical and Diagnostic Research central nervous system tumours cytological-histological comparison cytomorphological features squash smear cytology |
author_facet |
GOWRI PRAKASAM K KARKUZHALI VEERARAGHAVAN GURUSAMY |
author_sort |
GOWRI PRAKASAM |
title |
Role of Squash Cytology in Intraoperative Diagnosis of Meningioma |
title_short |
Role of Squash Cytology in Intraoperative Diagnosis of Meningioma |
title_full |
Role of Squash Cytology in Intraoperative Diagnosis of Meningioma |
title_fullStr |
Role of Squash Cytology in Intraoperative Diagnosis of Meningioma |
title_full_unstemmed |
Role of Squash Cytology in Intraoperative Diagnosis of Meningioma |
title_sort |
role of squash cytology in intraoperative diagnosis of meningioma |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2021-08-01 |
description |
Introduction: Primary Central Nervous System (CNS) tumours
constitute less than 2% of overall cancers in adults and are
the second most frequently encountered tumours in children.
Meningiomas form 24-30% of primary intracranial tumours.
Most intrinsic brain tumours are soft and gelatinous in
consistency, smear preparation can readily made which gives
excellent cytological details when compared to frozen section
as the latter produces ice crystal artifacts.
Aim: To assess the diagnostic utility of squash cytological
evaluation of meningiomas and its comparison with final
histopathological diagnosis.
Materials and Methods: The cross-sectional study was done
at Thanjavur Medical College, Thanjavur, Tamil Nadu, India for
period of three years from January 2015 to December 2017.
Total of 54 clinically diagnosed and radiologically suspected
case of meningiomas were selected. Smears were prepared
from the biopsy samples sent in normal saline and stained by
Haematoxylin and Eosin (H&E) method. The cytological features
were noted and matched with biopsy findings. Descriptive
statistics were used to analyse the results.
Results: Total of 54 squash smears with male to female ratio
was 1:1.5. Maximum number of cases were seen between 41-
50 years followed by 51-60 years. Complete concordance was
obtained in 51 cases (94.44%) and partial concordance was
noted in a case due to underestimation of malignancy grade in
squash cytology. Out of 54 cases, two cases were found to be
discordant with final histopathological diagnosis.
Conclusion: Intraoperative squash cytology is easy, rapid,
reliable and cost-effective technique for neurosurgical
consultation with fairly high accuracy in diagnosing
meningiomas. |
topic |
central nervous system tumours cytological-histological comparison cytomorphological features squash smear cytology |
url |
https://jcdr.net/articles/PDF/15260/47878_CE[Ra1]_F[SK]_PF1(SC_OM)_PFA(SC_KM)_PN(KM).pdf |
work_keys_str_mv |
AT gowriprakasam roleofsquashcytologyinintraoperativediagnosisofmeningioma AT kkarkuzhali roleofsquashcytologyinintraoperativediagnosisofmeningioma AT veeraraghavangurusamy roleofsquashcytologyinintraoperativediagnosisofmeningioma |
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1716838401653604352 |