The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis
Objective. The aim of this meta-analysis was to systematically evaluate the effectiveness and safety of the traditional Chinese medicine (TCM) formula Bushen Huoxue Decoction (BSHXD) in treating coronary heart disease (CHD). Methods. Randomized controlled trials (RCTS) of BSHXD in treating CHD were...
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Hindawi Limited
2021-01-01
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Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2021/5541228 |
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doaj-0c5c62ba7c974f4a8809409df2c389602021-06-21T02:24:49ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-42882021-01-01202110.1155/2021/5541228The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-AnalysisLan-Chun Liu0Qi-Yuan Mao1Chao Liu2Jun Hu3Lian Duan4Jie Wang5Cardiovascular DepartmentBeijing University of Chinese MedicineCardiovascular DepartmentCardiovascular DepartmentCardiovascular DepartmentCardiovascular DepartmentObjective. The aim of this meta-analysis was to systematically evaluate the effectiveness and safety of the traditional Chinese medicine (TCM) formula Bushen Huoxue Decoction (BSHXD) in treating coronary heart disease (CHD). Methods. Randomized controlled trials (RCTS) of BSHXD in treating CHD were searched until March 2020, through six electronic databases: PubMed, Cochrane Library, CNKI, WanFang, SinoMed, and VIP. This study used the Cochrane Risk Test bias tool in the Cochrane Handbook to assess the quality of the methodology. Review Manager (RevMan) 5.3 was used to analyze the results. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were applied in the classification of evidence quality. Results. Ten RCTs involving 901 patients were finally included in this meta-analysis. It revealed that the effectiveness of BSHXD in treating CHD was significantly better than that of the conventional western medicine (CWM) treatment (P<0.00001). The effective rate of BSHXD treatment group on ECG was also significantly higher than that of CWM group (P<0.00001). The low-density lipoprotein cholesterol was decreased in the treatment groups compared with those in the control groups (P<0.00001). There was also a reduction in frequency and duration of angina pectoris (P<0.00001). There were no significant differences in TC level (P=0.08), TG level (P=0.86), and HDL level (P=0.76) between the treatment and control groups. Five studies had informed adverse events, including nausea and diarrhea. Conclusion. Our findings laid the foundation to the use of TCM Formula BSHXD in combination with conventional western medicine for treating CHD. However, due to the limitation of the quality of the included researches, in addition to potential reporting bias, the above conclusions still need verification by higher-quality and better-designed studies.http://dx.doi.org/10.1155/2021/5541228 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lan-Chun Liu Qi-Yuan Mao Chao Liu Jun Hu Lian Duan Jie Wang |
spellingShingle |
Lan-Chun Liu Qi-Yuan Mao Chao Liu Jun Hu Lian Duan Jie Wang The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis Evidence-Based Complementary and Alternative Medicine |
author_facet |
Lan-Chun Liu Qi-Yuan Mao Chao Liu Jun Hu Lian Duan Jie Wang |
author_sort |
Lan-Chun Liu |
title |
The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis |
title_short |
The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis |
title_full |
The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis |
title_fullStr |
The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis |
title_full_unstemmed |
The Effectiveness and Safety of Bushen Huoxue Decoction on Treating Coronary Heart Disease: A Meta-Analysis |
title_sort |
effectiveness and safety of bushen huoxue decoction on treating coronary heart disease: a meta-analysis |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-4288 |
publishDate |
2021-01-01 |
description |
Objective. The aim of this meta-analysis was to systematically evaluate the effectiveness and safety of the traditional Chinese medicine (TCM) formula Bushen Huoxue Decoction (BSHXD) in treating coronary heart disease (CHD). Methods. Randomized controlled trials (RCTS) of BSHXD in treating CHD were searched until March 2020, through six electronic databases: PubMed, Cochrane Library, CNKI, WanFang, SinoMed, and VIP. This study used the Cochrane Risk Test bias tool in the Cochrane Handbook to assess the quality of the methodology. Review Manager (RevMan) 5.3 was used to analyze the results. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria were applied in the classification of evidence quality. Results. Ten RCTs involving 901 patients were finally included in this meta-analysis. It revealed that the effectiveness of BSHXD in treating CHD was significantly better than that of the conventional western medicine (CWM) treatment (P<0.00001). The effective rate of BSHXD treatment group on ECG was also significantly higher than that of CWM group (P<0.00001). The low-density lipoprotein cholesterol was decreased in the treatment groups compared with those in the control groups (P<0.00001). There was also a reduction in frequency and duration of angina pectoris (P<0.00001). There were no significant differences in TC level (P=0.08), TG level (P=0.86), and HDL level (P=0.76) between the treatment and control groups. Five studies had informed adverse events, including nausea and diarrhea. Conclusion. Our findings laid the foundation to the use of TCM Formula BSHXD in combination with conventional western medicine for treating CHD. However, due to the limitation of the quality of the included researches, in addition to potential reporting bias, the above conclusions still need verification by higher-quality and better-designed studies. |
url |
http://dx.doi.org/10.1155/2021/5541228 |
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