Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease

Cyclosporine A and IFNγ licencing enhances human mesenchymal stromal cell potency in a humanised mouse model of acute graft versus host disease

Abstract Immunosuppressive ability in human MSC donors has been shown to be variable and may be a limiting factor in MSC therapeutic efficacy in vivo. The importance of cytokine activation of mesenchymal stromal cells (MSCs) to facilitate their immunosuppressive function is well established. This st...

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Bibliographic Details
Main Authors: Jennifer M. Corbett, Ian Hawthorne, Hazel Dunbar, Ivan Coulter, Mairead Ni Chonghaile, Catherine M. Flynn, Karen English
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Stem Cell Research & Therapy
Subjects:
MSC cell therapy
Immunosuppressive drugs
Cyclosporine A
IFNγ
GvHD
SOCS1
Online Access:https://doi.org/10.1186/s13287-021-02309-6

Internet

https://doi.org/10.1186/s13287-021-02309-6

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