Chronic activation of the innate immune system may underlie the metabolic syndrome
CONTEXTO: The metabolic syndrome is characterized by a clustering, in free-living populations, of cardiovascular and diabetes risk factors generally linked to insulin resistance, obesity and central obesity. Consonant with the well-established inflammatory pathogenesis of atherosclerotic disease, th...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Associação Paulista de Medicina
2001-05-01
|
Series: | São Paulo Medical Journal |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300008&lng=en&tlng=en |
id |
doaj-0d1f871cd9f64535a8122fe1167bd1fb |
---|---|
record_format |
Article |
spelling |
doaj-0d1f871cd9f64535a8122fe1167bd1fb2020-11-25T00:30:35ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602001-05-01119312212710.1590/S1516-31802001000300008S1516-31802001000300008Chronic activation of the innate immune system may underlie the metabolic syndromeBruce Bartholow Duncan0Maria Inês Schmidt1Universidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulCONTEXTO: The metabolic syndrome is characterized by a clustering, in free-living populations, of cardiovascular and diabetes risk factors generally linked to insulin resistance, obesity and central obesity. Consonant with the well-established inflammatory pathogenesis of atherosclerotic disease, the metabolic syndrome is now being investigated in relation to its inflammatory nature. OBJETIVO: We present cross-sectional findings demonstrating that markers of inflammation correlate with components of the metabolic syndrome, and prospective findings of the ARIC Study indicating that markers of inflammation and endothelial dysfunction predict the development of diabetes mellitus and weight gain in adults. We present biological evidence to suggest that chronic activation of the innate immune system may underlie the metabolic syndrome, characterizing the common soil for the causality of type 2 diabetes mellitus and cardiovascular disease. CONCLUSIONS: Better understanding of the role of the innate immune system in these diseases may lead to important advances in the prediction and management of diabetes and cardiovascular disease.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300008&lng=en&tlng=enInflammationCytokinesNon-insulin dependent diabetes mellitusCardiovascular diseaseObesitySyndrome X |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bruce Bartholow Duncan Maria Inês Schmidt |
spellingShingle |
Bruce Bartholow Duncan Maria Inês Schmidt Chronic activation of the innate immune system may underlie the metabolic syndrome São Paulo Medical Journal Inflammation Cytokines Non-insulin dependent diabetes mellitus Cardiovascular disease Obesity Syndrome X |
author_facet |
Bruce Bartholow Duncan Maria Inês Schmidt |
author_sort |
Bruce Bartholow Duncan |
title |
Chronic activation of the innate immune system may underlie the metabolic syndrome |
title_short |
Chronic activation of the innate immune system may underlie the metabolic syndrome |
title_full |
Chronic activation of the innate immune system may underlie the metabolic syndrome |
title_fullStr |
Chronic activation of the innate immune system may underlie the metabolic syndrome |
title_full_unstemmed |
Chronic activation of the innate immune system may underlie the metabolic syndrome |
title_sort |
chronic activation of the innate immune system may underlie the metabolic syndrome |
publisher |
Associação Paulista de Medicina |
series |
São Paulo Medical Journal |
issn |
1806-9460 |
publishDate |
2001-05-01 |
description |
CONTEXTO: The metabolic syndrome is characterized by a clustering, in free-living populations, of cardiovascular and diabetes risk factors generally linked to insulin resistance, obesity and central obesity. Consonant with the well-established inflammatory pathogenesis of atherosclerotic disease, the metabolic syndrome is now being investigated in relation to its inflammatory nature. OBJETIVO: We present cross-sectional findings demonstrating that markers of inflammation correlate with components of the metabolic syndrome, and prospective findings of the ARIC Study indicating that markers of inflammation and endothelial dysfunction predict the development of diabetes mellitus and weight gain in adults. We present biological evidence to suggest that chronic activation of the innate immune system may underlie the metabolic syndrome, characterizing the common soil for the causality of type 2 diabetes mellitus and cardiovascular disease. CONCLUSIONS: Better understanding of the role of the innate immune system in these diseases may lead to important advances in the prediction and management of diabetes and cardiovascular disease. |
topic |
Inflammation Cytokines Non-insulin dependent diabetes mellitus Cardiovascular disease Obesity Syndrome X |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802001000300008&lng=en&tlng=en |
work_keys_str_mv |
AT brucebartholowduncan chronicactivationoftheinnateimmunesystemmayunderliethemetabolicsyndrome AT mariainesschmidt chronicactivationoftheinnateimmunesystemmayunderliethemetabolicsyndrome |
_version_ |
1725326026361274368 |