Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3R451C Mouse Model of Autism

Altered Amygdala Excitation and CB1 Receptor Modulation of Aggressive Behavior in the Neuroligin-3R451C Mouse Model of Autism

Understanding neuronal mechanisms underlying aggression in patients with autism spectrum disorder (ASD) could lead to better treatments and prognosis. The Neuroligin-3 (NL3)R451C mouse model of ASD has a heightened aggressive phenotype, however the biological mechanisms underlying this behavior are...

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Bibliographic Details
Main Authors: Suzanne Hosie, Daniel T. Malone, Stephanie Liu, Michelle Glass, Paul Anthony Adlard, Anthony John Hannan, Elisa L. Hill-Yardin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autism spectrum disorder
neuroligin
synaptic currents
aggression
cannabinoid receptor
WIN-55212-2
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00234/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00234/full

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