Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42

A key event in Alzheimer's disease (AD) pathogenesis is the conversion of the peptide beta-amyloid (Aβ) from its soluble monomeric form into various aggregated morphologies in the brain. Preventing aggregation of Aβ is being actively pursued as a primary therapeutic strategy for treating AD. Tr...

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Bibliographic Details
Main Authors: Ruitian Liu, Hedieh Barkhordarian, Sharareh Emadi, Chan Beum Park, Michael R. Sierks
Format: Article
Language:English
Published: Elsevier 2005-10-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Beta-amyloid
Trehalose
Aggregation
Atomic force microscope
Cytotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000628

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http://www.sciencedirect.com/science/article/pii/S0969996105000628

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