T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation

T Cell Mediated Conversion of a Non-Anti-La Reactive B Cell to an Autoreactive Anti-La B Cell by Somatic Hypermutation

Since the first description of nuclear autoantigens in the late 1960s and early 1970s, researchers, including ourselves, have found it difficult to establish monoclonal antibodies (mabs) against nuclear antigens, including the La/SS-B (Sjögrens’ syndrome associated antigen B) autoantigen. To date, o...

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Bibliographic Details
Main Authors: Michael P. Bachmann, Tabea Bartsch, Claudia C. Bippes, Dominik Bachmann, Edinson Puentes-Cala, Jennifer Bachmann, Holger Bartsch, Claudia Arndt, Stefanie Koristka, Liliana R. Loureiro, Alexandra Kegler, Markus Laube, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Marc Schmitz, Anja Feldmann
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
anti-La/SS-B antibodies
autoimmunity
La/SS-B autoantigen
systemic lupus erythematosus
primary Sjögren’s syndrome
Online Access:https://www.mdpi.com/1422-0067/22/3/1198

Internet

https://www.mdpi.com/1422-0067/22/3/1198

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