Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells

Thrombospondin-1 Receptor CD47 Overexpression Contributes to P-Glycoprotein-Mediated Multidrug Resistance Against Doxorubicin in Thyroid Carcinoma FTC-133 Cells

It is now admitted that in addition to acquired resistance, the tumor microenvironment contributes to the development of chemo-resistance and malignant progression. In a previous study, we showed that Dox induced apoptosis in FTC-133 cells by trigging JNK pathway. This process was accompanied by a d...

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Bibliographic Details
Main Authors: Marie-Pierre Courageot, Laurent Duca, Laurent Martiny, Emmanuelle Devarenne-Charpentier, Hamid Morjani, Hassan El Btaouri
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Oncology
Subjects:
chemo-resistance
doxorubicin
P-glycoprotein
TSP-1
CD47
thyroid carcinoma cells
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.551228/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2020.551228/full

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