Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population

To determine the performance of the updated Schwartz, combined Schwartz and Grubb glomerular filtration rate (GFR) equations in a relatively large number of healthy children with no known renal disease, we studied 712 students aged between seven and 18 years from the Isfahan province of Iran by rand...

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Main Authors: Alaleh Gheissari, Peyman Roomizadeh, Roya Kelishadi, Amin Abedini, Shaghayegh Haghjooy-Javanmard, Seyed-Hossein Abtahi, Bahareh Mehdikhani
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Saudi Journal of Kidney Diseases and Transplantation
Online Access:http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=5;spage=1004;epage=1010;aulast=Gheissari
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spelling doaj-0dd51284088b49d4b2f9d8c01f0e58ca2020-11-24T23:34:03ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422014-01-012551004101010.4103/1319-2442.139890Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric populationAlaleh GheissariPeyman RoomizadehRoya KelishadiAmin AbediniShaghayegh Haghjooy-JavanmardSeyed-Hossein AbtahiBahareh MehdikhaniTo determine the performance of the updated Schwartz, combined Schwartz and Grubb glomerular filtration rate (GFR) equations in a relatively large number of healthy children with no known renal disease, we studied 712 students aged between seven and 18 years from the Isfahan province of Iran by random cluster sampling between 2009 and 2010. Blood investigations included blood urea nitrogen, creatinine and cystatin C. For each participant, GFR was calculated based on the three equations. We used Bland-Altman plots and weighted kappa statistics to compare the performance of the study equations. The mean age of the children was 12.2 ± 2.4 years. A high concordance in estimating GFR (mean difference: 0 ± 12.7 mL/min/1.73 m 2 ) and a very good agreement in defining chronic kidney disease (CKD) and non-CKD individuals (weighted kappa: 0.85; 95% confidence intervals: 0.69-1) were observed between the updated Schwartz and the combined Schwartz equations. Poor agreement was observed between the Grubb equation and two Schwartz equations in estimating GFR and defining CKD. There was no systematic deviation between the updated Schwartz and the combined Schwartz equations in children with normal renal function. The Grubb equation was highly inconsistent with both Schwartz equations in this population. We conclude that the updated Schwartz equation is simpler and more accessible than the combined Schwartz equation in daily clinical practice and CKD screening programs.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=5;spage=1004;epage=1010;aulast=Gheissari
collection DOAJ
language English
format Article
sources DOAJ
author Alaleh Gheissari
Peyman Roomizadeh
Roya Kelishadi
Amin Abedini
Shaghayegh Haghjooy-Javanmard
Seyed-Hossein Abtahi
Bahareh Mehdikhani
spellingShingle Alaleh Gheissari
Peyman Roomizadeh
Roya Kelishadi
Amin Abedini
Shaghayegh Haghjooy-Javanmard
Seyed-Hossein Abtahi
Bahareh Mehdikhani
Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population
Saudi Journal of Kidney Diseases and Transplantation
author_facet Alaleh Gheissari
Peyman Roomizadeh
Roya Kelishadi
Amin Abedini
Shaghayegh Haghjooy-Javanmard
Seyed-Hossein Abtahi
Bahareh Mehdikhani
author_sort Alaleh Gheissari
title Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population
title_short Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population
title_full Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population
title_fullStr Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population
title_full_unstemmed Comparison of the performance of the updated Schwartz, combined Schwartz and the Grubb glomerular filtration rate equations in a general pediatric population
title_sort comparison of the performance of the updated schwartz, combined schwartz and the grubb glomerular filtration rate equations in a general pediatric population
publisher Wolters Kluwer Medknow Publications
series Saudi Journal of Kidney Diseases and Transplantation
issn 1319-2442
publishDate 2014-01-01
description To determine the performance of the updated Schwartz, combined Schwartz and Grubb glomerular filtration rate (GFR) equations in a relatively large number of healthy children with no known renal disease, we studied 712 students aged between seven and 18 years from the Isfahan province of Iran by random cluster sampling between 2009 and 2010. Blood investigations included blood urea nitrogen, creatinine and cystatin C. For each participant, GFR was calculated based on the three equations. We used Bland-Altman plots and weighted kappa statistics to compare the performance of the study equations. The mean age of the children was 12.2 ± 2.4 years. A high concordance in estimating GFR (mean difference: 0 ± 12.7 mL/min/1.73 m 2 ) and a very good agreement in defining chronic kidney disease (CKD) and non-CKD individuals (weighted kappa: 0.85; 95% confidence intervals: 0.69-1) were observed between the updated Schwartz and the combined Schwartz equations. Poor agreement was observed between the Grubb equation and two Schwartz equations in estimating GFR and defining CKD. There was no systematic deviation between the updated Schwartz and the combined Schwartz equations in children with normal renal function. The Grubb equation was highly inconsistent with both Schwartz equations in this population. We conclude that the updated Schwartz equation is simpler and more accessible than the combined Schwartz equation in daily clinical practice and CKD screening programs.
url http://www.sjkdt.org/article.asp?issn=1319-2442;year=2014;volume=25;issue=5;spage=1004;epage=1010;aulast=Gheissari
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