Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies

Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies

Abstract In the search of biguanide-derived molecules against melanoma, we have discovered and developed a series of bioactive products and identified the promising new compound CRO15. This molecule exerted anti-melanoma effects on cells lines and cells isolated from patients including the ones deri...

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Bibliographic Details
Main Authors: Emilie Jaune, Elisa Cavazza, Cyril Ronco, Oleksandr Grytsai, Patricia Abbe, Nedra Tekaya, Marwa Zerhouni, Guillaume Beranger, Lisa Kaminski, Frédéric Bost, Maeva Gesson, Meri Tulic, Paul Hofman, Robert Ballotti, Thierry Passeron, Thomas Botton, Rachid Benhida, Stéphane Rocchi
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03344-6

Internet

https://doi.org/10.1038/s41419-020-03344-6

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