IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice

IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice

The role of IL-12 in excitotoxic neurodegeneration of brain is largely unknown. To address this issue, we used the model of kainic acid (KA)-induced hippocampal injury in IL-12p35 knockout (KO) mice, a well-characterized model for human neurodegenerative diseases. After KA treatment, hippocampal neu...

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Bibliographic Details
Main Authors: Zhiguo Chen, Rui-Sheng Duan, Q. Hernan Concha, Qinyang Wu, Eilhard Mix, Bengt Winblad, Hans-Gustaf Ljunggren, Jie Zhu
Format: Article
Language:English
Published: Elsevier 2004-11-01
Series:Neurobiology of Disease
Subjects:
Kainic acid
IL-12p35 deficiency
Neurodegeneration
Microglia
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001718

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http://www.sciencedirect.com/science/article/pii/S0969996104001718

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