Human Ovarian Cancer Tissue Exhibits Increase of Mitochondrial Biogenesis and Cristae Remodeling

Human Ovarian Cancer Tissue Exhibits Increase of Mitochondrial Biogenesis and Cristae Remodeling

Ovarian cancer (OC) is the most lethal gynecologic cancer characterized by an elevated apoptosis resistance that, potentially, leads to chemo-resistance in the recurrent disease. Mitochondrial oxidative phosphorylation was found altered in OC, and mitochondria were proposed as a target for therapy....

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Bibliographic Details
Main Authors: Anna Signorile, Domenico De Rasmo, Antonella Cormio, Clara Musicco, Roberta Rossi, Francesco Fortarezza, Luigi Leonardo Palese, Vera Loizzi, Leonardo Resta, Giovanni Scillitani, Ettore Cicinelli, Francesca Simonetti, Anna Ferretta, Silvia Russo, Antonio Tufaro, Gennaro Cormio
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
ovarian cancer
mitochondria
cAMP
mitochondrial biogenesis
oxidative phosphorylation system (OXPHOS)
SIRT3
OPA1
prohibitins
Online Access:https://www.mdpi.com/2072-6694/11/9/1350

Internet

https://www.mdpi.com/2072-6694/11/9/1350

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