ApoE Polymorphism Is Associated With C-Reactive Protein in Low-HDL Family Members and in Normolipidemic Subjects
The study was aimed to compare inflammatory parameters between carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4 phenotypes) and those of carrying apoE3 isoform without apoE4 isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The concentrations of serum hsCRP, sVCAM-1, sICAM-1, and sE-sele...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/12587 |
| Summary: | The study was aimed to compare inflammatory parameters between
carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4
phenotypes) and those of carrying apoE3 isoform without apoE4
isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The
concentrations of serum hsCRP, sVCAM-1, sICAM-1, and sE-selectin
were measured in 211 subjects from Finnish low-HDL families and in
157 normolipidemic subjects. The subjects with apoE4 isoform had
lower concentrations of serum hsCRP both in low-HDL family members
(p<0.05) and in normolipidemic subjects (p<0.01). The
differences in serum CRP values remained significant after
adjustment for age, BMI, smoking status, hypertension, gender,
lipoprotein variables, and family number. We conclude that apoE
phenotype has a strong influence on serum CRP values. |
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| ISSN: | 0962-9351 1466-1861 |