Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO<sub>2</sub> Nanoparticles on SH-SY5Y Cells

Suitability of the In Vitro Cytokinesis-Block Micronucleus Test for Genotoxicity Assessment of TiO<sub>2</sub> Nanoparticles on SH-SY5Y Cells

Standard toxicity tests might not be fully adequate for evaluating nanomaterials since their unique features are also responsible for unexpected interactions. The in vitro cytokinesis-block micronucleus (CBMN) test is recommended for genotoxicity testing, but cytochalasin-B (Cyt-B) may interfere wit...

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Bibliographic Details
Main Authors: Natalia Fernández-Bertólez, Fátima Brandão, Carla Costa, Eduardo Pásaro, João Paulo Teixeira, Blanca Laffon, Vanessa Valdiglesias
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
cytochalasin-B
cytokinesis-block micronucleus test
flow cytometry micronucleus test
nanomaterials
TiO<sub>2</sub> nanoparticles
SH-SY5Y cells
Online Access:https://www.mdpi.com/1422-0067/22/16/8558

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https://www.mdpi.com/1422-0067/22/16/8558

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