Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation

Streptococcus pneumoniae is an opportunistic pathogen and asymptomatic colonization is a precursor for invasive disease. Here the authors show rapid within-host evolution of naturally acquired pneumococci in ninety-eight infants driven by high nucleotide substitution rates and intra-host homologous...

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Main Authors: Chrispin Chaguza, Madikay Senghore, Ebrima Bojang, Rebecca A. Gladstone, Stephanie W. Lo, Peggy-Estelle Tientcheu, Rowan E. Bancroft, Archibald Worwui, Ebenezer Foster-Nyarko, Fatima Ceesay, Catherine Okoi, Lesley McGee, Keith P. Klugman, Robert F. Breiman, Michael R. Barer, Richard A. Adegbola, Martin Antonio, Stephen D. Bentley, Brenda A. Kwambana-Adams
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17327-w

Internet

https://doi.org/10.1038/s41467-020-17327-w

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