Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test
The aim of this study was to evaluate the association between the frequency of micronuclei (MN) and the cellular changes detected in the conventional Papanicolaou test. One hundred and seventy-four Papanicolaou test smears with cellular changes were examined. MN screening was done in cytopathologica...
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Sociedade Brasileira de Genética
2014-09-01
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doaj-0ecffe33857d437bac6c59c0001eca8f2020-11-25T00:36:24ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852014-09-0137349649910.1590/S1415-47572014000400004S1415-47572014000400004Association between cervical lesion grade and micronucleus frequency in the Papanicolaou testCaroline Tanski Bueno0Cláudia Maria Dornelles da Silva1Regina Bones Barcellos2Juliana da Silva3Carla Rossana dos Santos4João Evangelista Sampaio Menezes5Honório Sampaio Menezes6Maria Lucia Rosa Rossetti7Universidade Luterana do BrasilFundação Estadual de Produção e Pesquisa em SaúdeFundação Estadual de Produção e Pesquisa em SaúdeUniversidade Luterana do BrasilUniversidade Luterana do BrasilLaboratório CediclinLaboratório CediclinFundação Estadual de Produção e Pesquisa em SaúdeThe aim of this study was to evaluate the association between the frequency of micronuclei (MN) and the cellular changes detected in the conventional Papanicolaou test. One hundred and seventy-four Papanicolaou test smears with cellular changes were examined. MN screening was done in cytopathological smears by counting 1,000 cervical cells in a light microscope. MN frequencies were significantly higher in the group with cellular changes compared to the control group (p < 0.001). The mean MN frequencies were 0.95 ± 1.12 (mean ± SD) in the control group (n = 223), 2.98 ± 1.20 in individuals with atypical squamous cells of undetermined significance (ASC-US) (n = 50), 4.04 ± 1.45 in cervical intraepithelial neoplasia (CIN) I (n = 52), 5.97 ± 1.83 in CIN II (n = 30), 7.29 ± 1.55 in CIN III (n = 17) and 8.64 ± 1.55 in invasive cancer (n = 25). These findings suggest that MN monitoring should be included as an additional criterion for the early detection of cytogenetic damage in routine examinations. This monitoring should be done in the same smear as used for cytopathological examination. More specific and systematic studies are necessary to confirm this proposal.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000400004&lng=en&tlng=encervical cancercervical lesionsmicronucleusPapanicolaou test |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Caroline Tanski Bueno Cláudia Maria Dornelles da Silva Regina Bones Barcellos Juliana da Silva Carla Rossana dos Santos João Evangelista Sampaio Menezes Honório Sampaio Menezes Maria Lucia Rosa Rossetti |
spellingShingle |
Caroline Tanski Bueno Cláudia Maria Dornelles da Silva Regina Bones Barcellos Juliana da Silva Carla Rossana dos Santos João Evangelista Sampaio Menezes Honório Sampaio Menezes Maria Lucia Rosa Rossetti Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test Genetics and Molecular Biology cervical cancer cervical lesions micronucleus Papanicolaou test |
author_facet |
Caroline Tanski Bueno Cláudia Maria Dornelles da Silva Regina Bones Barcellos Juliana da Silva Carla Rossana dos Santos João Evangelista Sampaio Menezes Honório Sampaio Menezes Maria Lucia Rosa Rossetti |
author_sort |
Caroline Tanski Bueno |
title |
Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test |
title_short |
Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test |
title_full |
Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test |
title_fullStr |
Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test |
title_full_unstemmed |
Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test |
title_sort |
association between cervical lesion grade and micronucleus frequency in the papanicolaou test |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1678-4685 |
publishDate |
2014-09-01 |
description |
The aim of this study was to evaluate the association between the frequency of micronuclei (MN) and the cellular changes detected in the conventional Papanicolaou test. One hundred and seventy-four Papanicolaou test smears with cellular changes were examined. MN screening was done in cytopathological smears by counting 1,000 cervical cells in a light microscope. MN frequencies were significantly higher in the group with cellular changes compared to the control group (p < 0.001). The mean MN frequencies were 0.95 ± 1.12 (mean ± SD) in the control group (n = 223), 2.98 ± 1.20 in individuals with atypical squamous cells of undetermined significance (ASC-US) (n = 50), 4.04 ± 1.45 in cervical intraepithelial neoplasia (CIN) I (n = 52), 5.97 ± 1.83 in CIN II (n = 30), 7.29 ± 1.55 in CIN III (n = 17) and 8.64 ± 1.55 in invasive cancer (n = 25). These findings suggest that MN monitoring should be included as an additional criterion for the early detection of cytogenetic damage in routine examinations. This monitoring should be done in the same smear as used for cytopathological examination. More specific and systematic studies are necessary to confirm this proposal. |
topic |
cervical cancer cervical lesions micronucleus Papanicolaou test |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000400004&lng=en&tlng=en |
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