randomizeR: An R Package for the Assessment and Implementation of Randomization in Clinical Trials

• Main Authors: Diane Uschner, David Schindler, Ralf-Dieter Hilgers, Nicole Heussen
• Format: Article
• Language: English
• Published: Foundation for Open Access Statistics 2018-06-01
• Series: Journal of Statistical Software
• Subjects: clinical trial; restricted randomization; selection bias; chronological bias; R
• Online Access: https://www.jstatsoft.org/index.php/jss/article/view/2729

Randomization in clinical trials is the key design technique to ensure the comparability of treatment groups. Although there exist a large number of software products which assist the researcher to implement randomization, no tool which would cover a wide range of procedures and allow the comparative evaluation of the procedures under practical restrictions has been proposed in the literature so far. The R package randomizeR addresses this need. The paper includes a detailed description of the randomizeR package that serves as a tutorial for the generation of randomization sequences and the assessment of randomization procedures.