Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

Stress-Induced Changes in the Lipid Microenvironment of β-(1,3)-d-Glucan Synthase Cause Clinically Important Echinocandin Resistance in Aspergillus fumigatus

Resistance to first-line triazole antifungal agents among Aspergillus species has prompted the use of second-line therapy with echinocandins. As the number of Aspergillus-infected patients treated with echinocandins is rising, clinical observations of drug resistance are also increasing, indicating...

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Bibliographic Details
Main Authors: Shruthi Satish, Cristina Jiménez-Ortigosa, Yanan Zhao, Min Hee Lee, Enriko Dolgov, Thomas Krüger, Steven Park, David W. Denning, Olaf Kniemeyer, Axel A. Brakhage, David S. Perlin
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
Aspergillus fumigatus
ROS
antifungal resistance
caspofungin
echinocandins
glucan synthase
glucan synthase inhibitors
lipids
Online Access:https://doi.org/10.1128/mBio.00779-19

Internet

https://doi.org/10.1128/mBio.00779-19

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