Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds
Bone-tissue defects affect millions of people worldwide. Despite being common treatment approaches, autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect. This has prompted researchers to explore novel bone-regeneration methods. In recent decades, the development of...
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doaj-0fb408d2f52d47caa19312721fb326d12021-08-12T04:35:09ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2021-11-0161141104140Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffoldsGuanyin Zhu0Tianxu Zhang1Miao Chen2Ke Yao3Xinqi Huang4Bo Zhang5Yazhen Li6Jun Liu7Yunbing Wang8Zhihe Zhao9State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Corresponding author.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, 610041, PR China; Corresponding author.State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China; Corresponding author.Bone-tissue defects affect millions of people worldwide. Despite being common treatment approaches, autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect. This has prompted researchers to explore novel bone-regeneration methods. In recent decades, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field. As researchers have provided deep insights into bone physiology and the bone-healing mechanism, various biomimicking and bioinspired BTE scaffolds have been reported. Now it is necessary to review the progress of natural bone physiology and bone healing mechanism, which will provide more valuable enlightenments for researchers in this field. This work details the physiological microenvironment of the natural bone tissue, bone-healing process, and various biomolecules involved therein. Next, according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism, it elaborates the biomimetic design of a scaffold, highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration.http://www.sciencedirect.com/science/article/pii/S2452199X21001547Bone tissue engineeringScaffoldBone biologyCytokineBone regeneration |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guanyin Zhu Tianxu Zhang Miao Chen Ke Yao Xinqi Huang Bo Zhang Yazhen Li Jun Liu Yunbing Wang Zhihe Zhao |
spellingShingle |
Guanyin Zhu Tianxu Zhang Miao Chen Ke Yao Xinqi Huang Bo Zhang Yazhen Li Jun Liu Yunbing Wang Zhihe Zhao Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds Bioactive Materials Bone tissue engineering Scaffold Bone biology Cytokine Bone regeneration |
author_facet |
Guanyin Zhu Tianxu Zhang Miao Chen Ke Yao Xinqi Huang Bo Zhang Yazhen Li Jun Liu Yunbing Wang Zhihe Zhao |
author_sort |
Guanyin Zhu |
title |
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds |
title_short |
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds |
title_full |
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds |
title_fullStr |
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds |
title_full_unstemmed |
Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds |
title_sort |
bone physiological microenvironment and healing mechanism: basis for future bone-tissue engineering scaffolds |
publisher |
KeAi Communications Co., Ltd. |
series |
Bioactive Materials |
issn |
2452-199X |
publishDate |
2021-11-01 |
description |
Bone-tissue defects affect millions of people worldwide. Despite being common treatment approaches, autologous and allogeneic bone grafting have not achieved the ideal therapeutic effect. This has prompted researchers to explore novel bone-regeneration methods. In recent decades, the development of bone tissue engineering (BTE) scaffolds has been leading the forefront of this field. As researchers have provided deep insights into bone physiology and the bone-healing mechanism, various biomimicking and bioinspired BTE scaffolds have been reported. Now it is necessary to review the progress of natural bone physiology and bone healing mechanism, which will provide more valuable enlightenments for researchers in this field. This work details the physiological microenvironment of the natural bone tissue, bone-healing process, and various biomolecules involved therein. Next, according to the bone physiological microenvironment and the delivery of bioactive factors based on the bone-healing mechanism, it elaborates the biomimetic design of a scaffold, highlighting the designing of BTE scaffolds according to bone biology and providing the rationale for designing next-generation BTE scaffolds that conform to natural bone healing and regeneration. |
topic |
Bone tissue engineering Scaffold Bone biology Cytokine Bone regeneration |
url |
http://www.sciencedirect.com/science/article/pii/S2452199X21001547 |
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