A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins

A Novel Therapeutic Mechanism of Imipridones ONC201/ONC206 in MYCN-Amplified Neuroblastoma Cells via Differential Expression of Tumorigenic Proteins

Neuroblastoma is the most common extracranial nervous system tumor in children. It presents with a spectrum of clinical prognostic measures ranging from benign growths that regress spontaneously to highly malignant, treatment evasive tumors affiliated with increased mortality rates. MYCN amplificati...

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Bibliographic Details
Main Authors: Sarra El-Soussi, Reine Hanna, Hanna Semaan, Amanda-Rose Khater, Jad Abdallah, Wassim Abou-Kheir, Tamara Abou-Antoun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Pediatrics
Subjects:
ONC201/ONC206
Pdgfrβ
L1CAM
HMGA1
FABP5
cancer stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.693145/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2021.693145/full

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