Efficacy of Colistin and Its Combination With Rifampin in Vitro and in Experimental Models of Infection Caused by Carbapenemase-Producing Clinical Isolates of Klebsiella pneumoniae

Despite the relevance of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) infections there are a scarce number of studies to evaluate in vivo the efficacy of combinations therapies. The bactericidal activity of colistin, rifampin, and its combination was studied (time–kill curves) against four...

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Main Authors: María E. Pachón-Ibáñez, Gema Labrador-Herrera, Tania Cebrero-Cangueiro, Caridad Díaz, Younes Smani, José P. del Palacio, Jesús Rodríguez-Baño, Alvaro Pascual, Jerónimo Pachón, M. Carmen Conejo
Format: Article
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Microbiology
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00912/full