A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair

A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair

<i>BRCA1</i> and <i>BRCA2</i> are the genes most frequently associated with hereditary breast and ovarian cancer (HBOC). They are crucial for the maintenance of genome stability, particularly in the homologous recombination-mediated repair pathway of DNA double-strand breaks...

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Bibliographic Details
Main Authors: Maria Valeria Esposito, Giuseppina Minopoli, Luciana Esposito, Valeria D’Argenio, Federica Di Maggio, Emanuele Sasso, Massimiliano D’Aiuto, Nicola Zambrano, Francesco Salvatore
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
cancer genomics
breast cancer
mutation
variant of uncertain significance (vus)
vus classification
dna damage repair
<i>brca2</i>
Online Access:https://www.mdpi.com/2072-6694/11/10/1454

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