Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences.

The completion of the human genome sequence has made possible genome-wide studies of retroviral DNA integration. Here we report an analysis of 3,127 integration site sequences from human cells. We compared retroviral vectors derived from human immunodeficiency virus (HIV), avian sarcoma-leukosis vir...

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Bibliographic Details
Main Authors: Rick S Mitchell, Brett F Beitzel, Astrid R W Schroder, Paul Shinn, Huaming Chen, Charles C Berry, Joseph R Ecker, Frederic D Bushman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2004-08-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC509299?pdf=render