Genetic Characteristics of Glioblastoma: Clinical Implications of Heterogeneity
Glioblastoma multiforme (GBM) is a heterogeneous group of tumors, each with its own distinct molecular and genetic signatures. This heterogeneity is a major clinical hurdle for classifying tumors and for devising effective personalized therapies targeting the disease pathways. Herein, the primary ge...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Cancer Translational Medicine |
| Subjects: | |
| Online Access: | http://www.cancertm.com/article.asp?issn=2395-3977;year=2015;volume=1;issue=5;spage=176;epage=180;aulast=Li |
| Summary: | Glioblastoma multiforme (GBM) is a heterogeneous group of tumors, each with its own distinct molecular and genetic signatures. This heterogeneity is a major clinical hurdle for classifying tumors and for devising effective personalized therapies targeting the disease pathways. Herein, the primary genetic and epigenetic alterations in GBM that have been used as therapeutic targets in clinical settings nowadays, with or without clinical benefits for patients, as well as the future directions for developing novel strategies were discussed. |
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| ISSN: | 2395-3977 2395-3012 |