Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.

Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.

BACKGROUND: Retinoid X receptor-alpha (RXRα) is a key member of the nuclear receptor superfamily. We recently demonstrated that proteolytic cleavage of RXRα resulted in production of a truncated product, tRXRα, which promotes cancer cell survival by activating phosphatidylinositol-3-OH kinase (PI3K)...

Full description

Bibliographic Details
Main Authors: Na Lu, Jinxing Liu, Jie Liu, Chunyun Zhang, Fuquan Jiang, Hua Wu, Liqun Chen, Wenjun Zeng, Xihua Cao, Tingdong Yan, Guanghui Wang, Hu Zhou, Bingzhen Lin, Xiaomei Yan, Xiao-kun Zhang, Jin-Zhang Zeng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3335786?pdf=render

Internet

http://europepmc.org/articles/PMC3335786?pdf=render

Similar Items