Novel Ferrocene Derivatives Induce Apoptosis through Mitochondria-Dependent and Cell Cycle Arrest via PI3K/Akt/mTOR Signaling Pathway in T Cell Acute Lymphoblastic Leukemia

Novel Ferrocene Derivatives Induce Apoptosis through Mitochondria-Dependent and Cell Cycle Arrest via PI3K/Akt/mTOR Signaling Pathway in T Cell Acute Lymphoblastic Leukemia

T cell acute lymphoblastic leukemia (T-ALL) is one of the most common causes of death in pediatric malignancies. However, the clinical chemotherapy for T-ALL has been limited by numerous side effects, emphasizing that novel anti-T-ALL drugs are urgently needed. Herein, a series of 2-acyl-1-dimethyla...

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Bibliographic Details
Main Authors: Liao Zeng, Mingqing Tang, Chao Pi, Jianrong Zheng, Sanxing Gao, Titaua Chabanne, Remi Chauvin, Wenzhao Cheng, Hongjun Lin, Ruian Xu, Xiuling Cui
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Cancers
Subjects:
ferrocene derivatives
T cell acute lymphoblastic leukemia
apoptosis
reactive oxygen species
mitochondrial membrane potential
cell cycle
Online Access:https://www.mdpi.com/2072-6694/13/18/4677

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https://www.mdpi.com/2072-6694/13/18/4677

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