Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Topoisomerase II is critical for DNA replication, transcription and chromosome segregation and is a well validated target of anti-neoplastic drugs including the anthracyclines and epipodophyllotoxins. However, these drugs are limited by common tumor resistance mechanisms and side-effect profiles. No...

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Bibliographic Details
Main Authors: Rachael E Hawtin, David E Stockett, Jo Ann W Byl, Robert S McDowell, Tan Nguyen, Michelle R Arkin, Andrew Conroy, Wenjin Yang, Neil Osheroff, Judith A Fox
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2855444?pdf=render

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http://europepmc.org/articles/PMC2855444?pdf=render

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