The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; he...

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Main Authors: Jing Chen, Chao Ye, Chao Wan, Gang Li, Lianci Peng, Yuanyi Peng, Rendong Fang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
JNK
Online Access:https://www.mdpi.com/1422-0067/22/17/9640
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spelling doaj-13e3dfb59452424290594bed00156ef82021-09-09T13:49:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-01229640964010.3390/ijms22179640The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious DiseasesJing Chen0Chao Ye1Chao Wan2Gang Li3Lianci Peng4Yuanyi Peng5Rendong Fang6Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, Chinac-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway’s role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases.https://www.mdpi.com/1422-0067/22/17/9640JNKapoptosisautophagyinfectious diseasesJNK inhibitors
collection DOAJ
language English
format Article
sources DOAJ
author Jing Chen
Chao Ye
Chao Wan
Gang Li
Lianci Peng
Yuanyi Peng
Rendong Fang
spellingShingle Jing Chen
Chao Ye
Chao Wan
Gang Li
Lianci Peng
Yuanyi Peng
Rendong Fang
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
International Journal of Molecular Sciences
JNK
apoptosis
autophagy
infectious diseases
JNK inhibitors
author_facet Jing Chen
Chao Ye
Chao Wan
Gang Li
Lianci Peng
Yuanyi Peng
Rendong Fang
author_sort Jing Chen
title The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
title_short The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
title_full The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
title_fullStr The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
title_full_unstemmed The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
title_sort roles of c-jun n-terminal kinase (jnk) in infectious diseases
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-09-01
description c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway’s role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases.
topic JNK
apoptosis
autophagy
infectious diseases
JNK inhibitors
url https://www.mdpi.com/1422-0067/22/17/9640
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