The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases
c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; he...
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doaj-13e3dfb59452424290594bed00156ef82021-09-09T13:49:00ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-01229640964010.3390/ijms22179640The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious DiseasesJing Chen0Chao Ye1Chao Wan2Gang Li3Lianci Peng4Yuanyi Peng5Rendong Fang6Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, ChinaJoint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, Chinac-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway’s role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases.https://www.mdpi.com/1422-0067/22/17/9640JNKapoptosisautophagyinfectious diseasesJNK inhibitors |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Chen Chao Ye Chao Wan Gang Li Lianci Peng Yuanyi Peng Rendong Fang |
spellingShingle |
Jing Chen Chao Ye Chao Wan Gang Li Lianci Peng Yuanyi Peng Rendong Fang The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases International Journal of Molecular Sciences JNK apoptosis autophagy infectious diseases JNK inhibitors |
author_facet |
Jing Chen Chao Ye Chao Wan Gang Li Lianci Peng Yuanyi Peng Rendong Fang |
author_sort |
Jing Chen |
title |
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases |
title_short |
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases |
title_full |
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases |
title_fullStr |
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases |
title_full_unstemmed |
The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases |
title_sort |
roles of c-jun n-terminal kinase (jnk) in infectious diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-09-01 |
description |
c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; hence, JNKs may play important roles in infectious diseases. In this review, we describe the basic signaling properties of MAPKs and JNKs in apoptosis, autophagy, and inflammasome activation. Furthermore, we discuss the roles of JNKs in various infectious diseases induced by viruses, bacteria, fungi, and parasites, as well as their potential to serve as targets for the development of therapeutic agents for infectious diseases. We expect this review to expand our understanding of the JNK signaling pathway’s role in infectious diseases and provide important clues for the prevention and treatment of infectious diseases. |
topic |
JNK apoptosis autophagy infectious diseases JNK inhibitors |
url |
https://www.mdpi.com/1422-0067/22/17/9640 |
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