TCR signaling emerges from the sum of many parts.

How does T cell receptor signaling begin? Answering this question requires an understanding of how the parts of the molecular machinery that mediates this process fit and work together. Ultimately this molecular architecture must (i) trigger the relay of information from the TCR-pMHC interface to th...

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Bibliographic Details
Main Authors: Michael S Kuhns, Mark M Davis
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-06-01
Series:Frontiers in Immunology
Subjects:
tcr
CD3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2012.00159/full