Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China
Abstract Background To investigate the associations between the perceived barriers and benefits of using HIV pre-exposure prophylaxis medication, including worries about the side effects, disliking taking drugs, perceived burden of taking medication, positive expectations as to the efficacy of the d...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2018-11-01
|
Series: | BMC Infectious Diseases |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12879-018-3497-7 |
id |
doaj-14764a7556364595b66afb324bd08b16 |
---|---|
record_format |
Article |
spelling |
doaj-14764a7556364595b66afb324bd08b162020-11-25T03:59:05ZengBMCBMC Infectious Diseases1471-23342018-11-011811810.1186/s12879-018-3497-7Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western ChinaYing Hu0Xiao-ni Zhong1Bin Peng2Yan Zhang3Hao Liang4Jiang-hong Dai5Ju-ying Zhang6Ai-long Huang7Department of Health Statistics and Information Management, School of Public Health and Management, Chongqing Medical UniversityDepartment of Health Statistics and Information Management, School of Public Health and Management, Chongqing Medical UniversityDepartment of Health Statistics and Information Management, School of Public Health and Management, Chongqing Medical UniversityDepartment of Health Statistics and Information Management, School of Public Health and Management, Chongqing Medical UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Guangxi Medical UniversityDepartment of Epidemiology and Health Statistics, School of Public Health, Xinjiang Medical UniversityDepartment of Epidemiology and Medical Statistics, School of Public Health, Sichuan UniversityKey Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Chongqing Medical UniversityAbstract Background To investigate the associations between the perceived barriers and benefits of using HIV pre-exposure prophylaxis medication, including worries about the side effects, disliking taking drugs, perceived burden of taking medication, positive expectations as to the efficacy of the drugs, favourable doctor-patient relationships, and medication adherence among men who have sex with men (MSM) to provide a target for improving medication adherence and reducing HIV infection among MSM. Methods MSM were recruited in western China from April 2013 to October 2014, administered oral tenofovir (TDF) daily and followed up every 12 weeks for 2 years. At each follow-up, the medication rate was calculated based on the self-reported number of missed doses over 2 weeks, and then, the medication adherence was evaluated. The barriers and benefits perceived during medication were obtained by a self-administered questionnaire, and their effects on medication adherence were analysed by linear mixed models. Results A total of 411 participants were enrolled in this study, and 1561 follow-up observation points were obtained. The average medication rate was 0.62 ± 0.37, and the medication rate increased with longer follow-up (P < 0.05). The medication rate was higher among MSM who were divorced (compared to those who were unmarried, P < 0.0001). MSM with more positive expectations as to the efficacy of the drugs showed higher rates of medication (P < 0.0001), while those who were more worried about side effects had a lower medication rate (P = 0.0208). In contrast, the dislike of taking the drugs and the burden perceived during medication had no effects on the actual medication rate of taking TDF (P > 0.05). Conclusion How to obtain and maintain high medication adherence among MSM is the key to the PrEP intervention strategy for effective reduction of HIV infection. For MSM in China, we should deepen their understanding of the effectiveness and safety of PrEP and increase their confidence in PrEP, thereby improving their medication adherence. Trial registration ChiCTR-TRC-13003849. Registered on 24/06/2013.http://link.springer.com/article/10.1186/s12879-018-3497-7Pre-exposure prophylaxis, PrEPMSMAdherenceBarriers and benefits |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ying Hu Xiao-ni Zhong Bin Peng Yan Zhang Hao Liang Jiang-hong Dai Ju-ying Zhang Ai-long Huang |
spellingShingle |
Ying Hu Xiao-ni Zhong Bin Peng Yan Zhang Hao Liang Jiang-hong Dai Ju-ying Zhang Ai-long Huang Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China BMC Infectious Diseases Pre-exposure prophylaxis, PrEP MSM Adherence Barriers and benefits |
author_facet |
Ying Hu Xiao-ni Zhong Bin Peng Yan Zhang Hao Liang Jiang-hong Dai Ju-ying Zhang Ai-long Huang |
author_sort |
Ying Hu |
title |
Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China |
title_short |
Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China |
title_full |
Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China |
title_fullStr |
Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China |
title_full_unstemmed |
Associations between perceived barriers and benefits of using HIV pre-exposure prophylaxis and medication adherence among men who have sex with men in Western China |
title_sort |
associations between perceived barriers and benefits of using hiv pre-exposure prophylaxis and medication adherence among men who have sex with men in western china |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2018-11-01 |
description |
Abstract Background To investigate the associations between the perceived barriers and benefits of using HIV pre-exposure prophylaxis medication, including worries about the side effects, disliking taking drugs, perceived burden of taking medication, positive expectations as to the efficacy of the drugs, favourable doctor-patient relationships, and medication adherence among men who have sex with men (MSM) to provide a target for improving medication adherence and reducing HIV infection among MSM. Methods MSM were recruited in western China from April 2013 to October 2014, administered oral tenofovir (TDF) daily and followed up every 12 weeks for 2 years. At each follow-up, the medication rate was calculated based on the self-reported number of missed doses over 2 weeks, and then, the medication adherence was evaluated. The barriers and benefits perceived during medication were obtained by a self-administered questionnaire, and their effects on medication adherence were analysed by linear mixed models. Results A total of 411 participants were enrolled in this study, and 1561 follow-up observation points were obtained. The average medication rate was 0.62 ± 0.37, and the medication rate increased with longer follow-up (P < 0.05). The medication rate was higher among MSM who were divorced (compared to those who were unmarried, P < 0.0001). MSM with more positive expectations as to the efficacy of the drugs showed higher rates of medication (P < 0.0001), while those who were more worried about side effects had a lower medication rate (P = 0.0208). In contrast, the dislike of taking the drugs and the burden perceived during medication had no effects on the actual medication rate of taking TDF (P > 0.05). Conclusion How to obtain and maintain high medication adherence among MSM is the key to the PrEP intervention strategy for effective reduction of HIV infection. For MSM in China, we should deepen their understanding of the effectiveness and safety of PrEP and increase their confidence in PrEP, thereby improving their medication adherence. Trial registration ChiCTR-TRC-13003849. Registered on 24/06/2013. |
topic |
Pre-exposure prophylaxis, PrEP MSM Adherence Barriers and benefits |
url |
http://link.springer.com/article/10.1186/s12879-018-3497-7 |
work_keys_str_mv |
AT yinghu associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT xiaonizhong associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT binpeng associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT yanzhang associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT haoliang associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT jianghongdai associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT juyingzhang associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina AT ailonghuang associationsbetweenperceivedbarriersandbenefitsofusinghivpreexposureprophylaxisandmedicationadherenceamongmenwhohavesexwithmeninwesternchina |
_version_ |
1724455673374179328 |