Meta‐inflammaging at the crossroad of geroscience
Abstract Geroscience posits that selected fundamental biological processes are the foundation of age‐related chronic diseases and are responsible for the decline in physical and mental function in old age. Late‐life chronic low‐grade inflammation (“inflammaging”) and altered signal transduction path...
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2019-09-01
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Online Access: | https://doi.org/10.1002/agm2.12078 |
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doaj-14b19e7f3f4d422483964d4d6f841c332021-05-02T17:23:39ZengWileyAging Medicine2475-03602019-09-012315716110.1002/agm2.12078Meta‐inflammaging at the crossroad of geroscienceGuobing Chen0Raymond Yung1Institute of Geriatric Immunology School of Medicine Jinan University Guangzhou ChinaGeriatrics Center and Institute of Gerontology University of Michigan Ann Arbor MI USAAbstract Geroscience posits that selected fundamental biological processes are the foundation of age‐related chronic diseases and are responsible for the decline in physical and mental function in old age. Late‐life chronic low‐grade inflammation (“inflammaging”) and altered signal transduction pathways in metabolism have been identified as two of the key themes in the aging process. Age‐related changes in the immune and metabolic responses are also recognized as playing a critical pathogenic role in most common chronic medical conditions that plague the elderly. Emerging investigations emphasize the interconnectedness of the immune and metabolic responses in aging, an area of gerontological research that can be termed “meta‐inflammaging.”https://doi.org/10.1002/agm2.12078geroscienceinflammagingmetabolic inflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Guobing Chen Raymond Yung |
spellingShingle |
Guobing Chen Raymond Yung Meta‐inflammaging at the crossroad of geroscience Aging Medicine geroscience inflammaging metabolic inflammation |
author_facet |
Guobing Chen Raymond Yung |
author_sort |
Guobing Chen |
title |
Meta‐inflammaging at the crossroad of geroscience |
title_short |
Meta‐inflammaging at the crossroad of geroscience |
title_full |
Meta‐inflammaging at the crossroad of geroscience |
title_fullStr |
Meta‐inflammaging at the crossroad of geroscience |
title_full_unstemmed |
Meta‐inflammaging at the crossroad of geroscience |
title_sort |
meta‐inflammaging at the crossroad of geroscience |
publisher |
Wiley |
series |
Aging Medicine |
issn |
2475-0360 |
publishDate |
2019-09-01 |
description |
Abstract Geroscience posits that selected fundamental biological processes are the foundation of age‐related chronic diseases and are responsible for the decline in physical and mental function in old age. Late‐life chronic low‐grade inflammation (“inflammaging”) and altered signal transduction pathways in metabolism have been identified as two of the key themes in the aging process. Age‐related changes in the immune and metabolic responses are also recognized as playing a critical pathogenic role in most common chronic medical conditions that plague the elderly. Emerging investigations emphasize the interconnectedness of the immune and metabolic responses in aging, an area of gerontological research that can be termed “meta‐inflammaging.” |
topic |
geroscience inflammaging metabolic inflammation |
url |
https://doi.org/10.1002/agm2.12078 |
work_keys_str_mv |
AT guobingchen metainflammagingatthecrossroadofgeroscience AT raymondyung metainflammagingatthecrossroadofgeroscience |
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1721489553705926656 |