The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons

The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons

The NO-cGMP signaling plays an important role in the regulation of striatal function although the mechanisms of action of cGMP specifically in medium spiny neurons (MSNs) remain unclear. Using genetically encoded fluorescent biosensors, including a novel Epac-based sensor (EPAC-SH150) with increased...

Full description

Bibliographic Details
Main Authors: Marina ePolito, Jeffrey eKlarenbeek, Kees eJalink, Danièle eTritsch, Pierre eVincent, Liliana R.V. Castro
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cyclic AMP
Cyclic GMP
Dopamine
Nitric Oxide
Striatum
phosphodiesterase
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00211/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00211/full

Similar Items