Development and characterisation of SMURF2-targeting modifiers

Development and characterisation of SMURF2-targeting modifiers

The C2-WW-HECT-domain E3 ubiquitin ligase SMURF2 emerges as an important regulator of diverse cellular processes. To date, SMURF2-specific modulators were not developed. Here, we generated and investigated a set of SMURF2-targeting synthetic peptides and peptidomimetics designed to stimulate SMURF2’...

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Bibliographic Details
Main Authors: Dhanoop Manikoth Ayyathan, Gal Levy-Cohen, Moran Shubely, Sandy Boutros-Suleiman, Veronica Lepechkin-Zilbermintz, Michael Shokhen, Amnon Albeck, Arie Gruzman, Michael Blank
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
smurf2
autoubiquitination
peptides
peptidomimetics
Online Access:http://dx.doi.org/10.1080/14756366.2020.1871337

Internet

http://dx.doi.org/10.1080/14756366.2020.1871337

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