OTU analysis using metagenomic shotgun sequencing data.

Because of technological limitations, the primer and amplification biases in targeted sequencing of 16S rRNA genes have veiled the true microbial diversity underlying environmental samples. However, the protocol of metagenomic shotgun sequencing provides 16S rRNA gene fragment data with natural immu...

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Bibliographic Details
Main Authors: Xiaolin Hao, Ting Chen
Format: Article
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3506635?pdf=render