Metabolism of propionic acid to a novel acyl-coenzyme A thioester by mammalian cell lines and platelets[S]

Metabolism of propionate involves the activated acyl-thioester propionyl-CoA intermediate. We employed LC-MS/MS, LC-selected reaction monitoring/MS, and LC-high-resolution MS to investigate metabolism of propionate to acyl-CoA intermediates. We discovered that propionyl-CoA can serve as a precursor...

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Bibliographic Details
Main Authors: Nathaniel W. Snyder, Sankha S. Basu, Andrew J. Worth, Clementina Mesaros, Ian A. Blair
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Journal of Lipid Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520356479