Increased CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner

Increased CD14+HLA-DR−/low Myeloid-Derived Suppressor Cells Correlate With Disease Severity in Systemic Lupus Erythematosus Patients in an iNOS-Dependent Manner

Myeloid-derived suppressor cells (MDSCs) comprise of a population of cells, which suppress the innate and adaptive immune system via different mechanisms. MDSCs are accumulated under pathological conditions. The present study aimed to clarify the pathological role of MDSCs in systemic lupus erythema...

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Bibliographic Details
Main Authors: Zhitao Wang, Fengfeng Zhu, Jiyu Wang, Qianshan Tao, Xuanxuan Xu, Huiping Wang, Shudao Xiong, Yiping Wang, Zhimin Zhai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
myeloid-derived suppressor cells
SLE
iNOS
disease severity
immunosuppression
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01202/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01202/full

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