Antiplasmodial activity is an ancient and conserved feature of tick defensins

Antiplasmodial activity is an ancient and conserved feature of tick defensins

Ancestral sequence reconstruction has been widely used to test evolution-based hypotheses. The genome of the European tick vector, Ixodes ricinus, encodes for defensin peptides with diverse antimicrobial activities against distantly related pathogens. These pathogens include fungi, Gram-negative and...

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Bibliographic Details
Main Authors: Alejandro Cabezas-Cruz, Miray Tonk, Anne Bouchut, Christine Pierrot, Raymond John Pierce, Michail Kotsyfakis, Mohammad Rahnamaeian, Andreas Vilcinskas, Jamal Khalife, James Jason Valdes
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Microbiology
Subjects:
Defensins
Plasmodium falciparum
Ticks
Antimicrobial spectrum
Ancestral sequence reconstruction
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01682/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01682/full

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