Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19

Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of COVID-19

Abstract Background Cross-reactivity to SARS-CoV-2 from exposure to endemic human coronaviruses (eHCoV) is gaining increasing attention as a possible driver of both protection against infection and COVID-19 severity. Here we explore the potential role of cross-reactivity induced by eHCoVs on age-spe...

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Bibliographic Details
Main Authors: Francesco Pinotti, Paul S. Wikramaratna, Uri Obolski, Robert S. Paton, Daniel S. C. Damineli, Luiz C. J. Alcantara, Marta Giovanetti, Sunetra Gupta, José Lourenço
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Medicine
Subjects:
COVID-19
SARS-CoV-2
Endemic coronaviruses
Cross-reactivity
Immunopathology
Mathematical model
Online Access:https://doi.org/10.1186/s12916-020-01887-1

Internet

https://doi.org/10.1186/s12916-020-01887-1

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