TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy.

TRPC6 single nucleotide polymorphisms and progression of idiopathic membranous nephropathy.

Activating mutations in the Transient Receptor Potential channel C6 (TRPC6) cause autosomal dominant focal segmental glomerular sclerosis (FSGS). TRPC6 expression is upregulated in renal biopsies of patients with idiopathic membranous glomerulopathy (iMN) and animal models thereof. In iMN, disease p...

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Bibliographic Details
Main Authors: Julia M Hofstra, Marieke J H Coenen, Mascha M V A P Schijvenaars, Jo H M Berden, Johan van der Vlag, Lies H Hoefsloot, Nine V A M Knoers, Jack F M Wetzels, Tom Nijenhuis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4096511?pdf=render

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http://europepmc.org/articles/PMC4096511?pdf=render

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