Cell counting in human endobronchial biopsies--disagreement of 2D versus 3D morphometry.

QUESTION: Inflammatory cell numbers are important endpoints in clinical studies relying on endobronchial biopsies. Assumption-based bidimensional (2D) counting methods are widely used, although theoretically design-based stereologic three-dimensional (3D) methods alone offer an unbiased quantitative...

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Bibliographic Details
Main Authors: Vlad A Bratu, Veit J Erpenbeck, Antonia Fehrenbach, Tanja Rausch, Susanne Rittinghausen, Norbert Krug, Jens M Hohlfeld, Heinz Fehrenbach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3963904?pdf=render