Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

Parkinson's disease (PD) is characterized by intracellular inclusions of aggregated and misfolded α-Synuclein (α-Syn), and the loss of dopaminergic (DA) neurons in the brain. The resulting motor abnormalities mark the progression of PD, while non-motor symptoms can already be identified during...

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Bibliographic Details
Main Authors: Jessika C. Bridi, Frank Hirth
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
Parkinson's disease
synapse
SNARE complex
active zone
dopamine
α-synuclein
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00080/full

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