Mutation and Epistasis in Influenza Virus Evolution

Influenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus’s capacity to generate diversit...

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Bibliographic Details
Main Authors: Daniel M. Lyons, Adam S. Lauring
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/10/8/407