The role of presepsin in the diagnosis and assessment of severity of sepsis and severe pneumonia

• Main Authors: E A TItova, A R Eyrikh, Z A Titova
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2018-11-01
• Series: Терапевтический архив
• Subjects: presepsin; pneumonia; sepsis
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/32876

The aim of this study was to evaluate marker of inflammation presepsin to improve diagnosis of severe pneumonia, sepsis. Materials and methods. 75 patients with pneumonia, sepsis, other inflammatory diseases aged from 17 to 78 years were examined. These patients have been investigated for the level of the presepsin. Presepsin level was quantified on immunohemilyuministsentny analyzer Pathfast (Mitsubishi Chemical Medience Corporation, Japan) in pg/ml. All patients had obtained an antibacterial therapy in other health care organizations before entering the hospital. Results. Presepsin at the general group of patients with pneumogenic sepsis was 3196.9±1202.16 pg/mL (n=14, x̅±m), with abdominal sepsis - 2506.7±448.32 pg/mL (n=28), with other inflammatory diseases - 671.6±124.55 pg/mL (n=11). Presepsin of patients with pneumogenic sepsis was 1125.3±240.59 pg/mL (n=3), presepsin of patients with severe pneumonia was - 362.6±76.29 pg/mL (n=13, p