Basement membrane fragility underlies embryonic lethality in fukutin-null mice

Fukuyama-type congenital muscular dystrophy (FCMD), associated with brain malformation due to defects in neuronal migration, is caused by mutations in fukutin. Several lines of evidence suggest that the fukutin protein plays a pivotal role in synthesis of O-mannosyl sugar moieties of α-dystroglycan,...

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Bibliographic Details
Main Authors: Hiroki Kurahashi, Mariko Taniguchi, Chikara Meno, Yoshihiro Taniguchi, Satoshi Takeda, Masato Horie, Hiroki Otani, Tatsushi Toda
Format: Article
Language:English
Published: Elsevier 2005-06-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105000021