Identification of pre-erythrocytic malaria antigens that target hepatocytes for killing in vivo and contribute to protection elicited by whole-parasite vaccination.

Identification of pre-erythrocytic malaria antigens that target hepatocytes for killing in vivo and contribute to protection elicited by whole-parasite vaccination.

Pre-erythrocytic malaria vaccines, including those based on whole-parasite approaches, have shown protective efficacy in animal and human studies. However few pre-erythocytic antigens other than the immunodominant circumsporozoite protein (CSP) have been studied in depth with the goal of developing...

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Bibliographic Details
Main Authors: Lin Chen, Gladys J Keitany, Xiaohong Peng, Claire Gibson, Isaac Mohar, Marissa Vignali, Ian N Crispe, Fusheng Huang, Ruobing Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4099202?pdf=render

Internet

http://europepmc.org/articles/PMC4099202?pdf=render

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