Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies

Oncolytic viruses encoding bispecific T cell engagers: a blueprint for emerging immunovirotherapies

Abstract Bispecific T cell engagers (BiTEs) are an innovative class of immunotherapeutics that redirect T cells to tumor surface antigens. While efficacious against certain hematological malignancies, limited bioavailability and severe toxicities have so far hampered broader clinical application, es...

Full description

Bibliographic Details
Main Authors: Johannes P. W. Heidbuechel, Christine E. Engeland
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Hematology & Oncology
Subjects:
Bispecific T cell engagers
Oncolytic viruses
Cancer immunotherapy
CAR T cells
Viral vectors
Immune checkpoint blockade
Online Access:https://doi.org/10.1186/s13045-021-01075-5

Internet

https://doi.org/10.1186/s13045-021-01075-5

Similar Items