Simultaneous inference of haplotypes and alleles at a causal gene

Simultaneous inference of haplotypes and alleles at a causal gene

We present a new methodology which jointly infers haplotypes and the causal alleles at a gene influencing a given trait. Often in human genetic studies, the available data consists of genotypes (series of genetic markers along the chromosomes) and a phenotype. However, for many genetic analyses, one...

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Bibliographic Details
Main Authors: Fabrice eLarribe, Mathieu J Dupont, Gabrielle eBoucher
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Genetics
Subjects:
Linkage Disequilibrium
EM algorithm
Case-Control Studies
Haplotype estimation
causal allele inference
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00291/full

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